| Greenville |
| No. 1 South Carolina vs. No. 16 Norfolk State |
| No. 8 South Florida vs. No. 9 Marquette |
| No. 5 Oklahoma vs. No. 12 Portland |
| No. 4 UCLA vs. No. 13 Sacramento State |
| No. 6 Creighton vs. No. 11 Illinois or Mississippi State (play-in winner) |
| No. 3 Notre Dame vs. No. 14 Southern Utah |
| No. 7 Arizona vs. No. 10 West Virginia |
| No. 2 Maryland vs. No. 15 Holy Cross |
|
| No. 1 Indiana vs. 16 Tennessee Tech or Monmouth (play-in winner) |
| No. 8 Oklahoma State vs. No. 9 Miami (Fla.) |
| No. 5 Washington State vs. No. 12 Florida Gulf Coast |
| No. 4 Villanova vs. No. 13 Cleveland State |
| No. 6 Michigan vs. No. 11 UNLV |
| No. 3 LSU vs. No. 14 Hawaii |
| No. 7 N.C. State vs. No. 10 Princeton |
| No. 2 Utah vs. No. 15 Gardner Webb |
|
| Seattle |
| No. 1 Virginia Tech vs. No. 16 Chattanooga |
| No. 8 Southern California vs. No. 9 South Dakota State |
| No. 5 Iowa State vs. No. 12 Toledo |
| No. 4 Tennessee vs. No. 13 Saint Louis |
| No. 6 North Carolina vs. No. 11 Purdue or St. John’s (play-in winner) |
| No. 3 Ohio State vs. No. 14 James Madison |
| No. 7 Baylor vs. No. 10 Alabama |
| No. 2 Connecticut vs. No. 15 Vermont |
|
| No. 1 Stanford vs. No. 16 Southern/Sacred Heart |
| No. 8 Mississippi vs. No. 9 Gonzaga |
| No. 5 Louisville vs. No. 12 Drake |
| No. 4 Texas vs. No. 13 East Carolina |
| No. 6 Colorado vs. No. 11 Middle Tennessee |
| No. 3 Duke vs. No. 14 Iona |
| No. 7 Florida State vs. No. 10 Georgia |
| No. 2 Iowa vs. No. 15 SE Louisiana |
